Glossary¶

This glossary provides definitions for terms and acronyms used in the context of C-COMPASS.

CA¶
class abundance¶: Median of protein amounts of a given class.
CC¶
class contribution¶: The relative fraction of a protein or other molecule type that is located in a specific compartment after filtering out false positives and re-normalizing the profile. \(CC \in [0, 1]\).
CC0¶: The class contributions before filtering# out false positives. I.e., the raw neural network output. \(CC0 \in [0, 1]\).
CPA¶: Compartment protein amount (CPA = CC * TPA)
DS¶: Distance score.
nCC¶: Normalized class contribution (nCC = CC * CA).
nCPA¶
normalized compartment protein amount¶: Relative protein amount on a specific compartment, normalized by changes in compartment abundance and protein expression levels. This value can be used for comparison between conditions only. nCPA = nCC * TPA.
profile¶: Here, a set of protein amounts across different fractions or compartments.
relocalization¶
RL¶: Relative change of protein localization for a specific compartment between two conditions. I.e., the difference between the class contributions of a given protein in the two conditions. \(RL \in [-1, 1]\).
relocalization score¶
RLS¶: Overall change of protein localization across all compartments (0 means no relocalization, 1 means 50% relocalization, 2 means full relocalization) between two conditions, regardless of their origin and destination. \(RLS \in [0, 2]\).
TPA¶: Total protein amount.

C-COMPASS